Cell type-specific pharmacology of NMDA receptors using masked MK801

N-Methyl-D-aspartate receptors (NMDA-Rs) are ion channels that are important for synaptic plasticity, which is involved in learning and drug addiction. We show enzymatic targeting of an NMDA-R antagonist, MK801, to a molecularly defined neuronal population with the cell-type-selectivity of genetic m...

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Detalles Bibliográficos
Autores principales: Yang, Yunlei, Lee, Peter, Sternson, Scott M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2015
Materias:
Biochemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4594264/
https://www.ncbi.nlm.nih.gov/pubmed/26359633
http://dx.doi.org/10.7554/eLife.10206
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author Yang, Yunlei
Lee, Peter
Sternson, Scott M
author_facet Yang, Yunlei
Lee, Peter
Sternson, Scott M
author_sort Yang, Yunlei
collection PubMed
description N-Methyl-D-aspartate receptors (NMDA-Rs) are ion channels that are important for synaptic plasticity, which is involved in learning and drug addiction. We show enzymatic targeting of an NMDA-R antagonist, MK801, to a molecularly defined neuronal population with the cell-type-selectivity of genetic methods and the temporal control of pharmacology. We find that NMDA-Rs on dopamine neurons are necessary for cocaine-induced synaptic potentiation, demonstrating that cell type-specific pharmacology can be used to dissect signaling pathways within complex brain circuits. DOI: http://dx.doi.org/10.7554/eLife.10206.001
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spelling pubmed-45942642015-10-07 Cell type-specific pharmacology of NMDA receptors using masked MK801 Yang, Yunlei Lee, Peter Sternson, Scott M eLife Biochemistry N-Methyl-D-aspartate receptors (NMDA-Rs) are ion channels that are important for synaptic plasticity, which is involved in learning and drug addiction. We show enzymatic targeting of an NMDA-R antagonist, MK801, to a molecularly defined neuronal population with the cell-type-selectivity of genetic methods and the temporal control of pharmacology. We find that NMDA-Rs on dopamine neurons are necessary for cocaine-induced synaptic potentiation, demonstrating that cell type-specific pharmacology can be used to dissect signaling pathways within complex brain circuits. DOI: http://dx.doi.org/10.7554/eLife.10206.001 eLife Sciences Publications, Ltd 2015-09-11 /pmc/articles/PMC4594264/ /pubmed/26359633 http://dx.doi.org/10.7554/eLife.10206 Text en © 2015, Yang et al http://creativecommons.org/licenses/by/4.0/ This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Biochemistry
Yang, Yunlei
Lee, Peter
Sternson, Scott M
Cell type-specific pharmacology of NMDA receptors using masked MK801
title Cell type-specific pharmacology of NMDA receptors using masked MK801
title_full Cell type-specific pharmacology of NMDA receptors using masked MK801
title_fullStr Cell type-specific pharmacology of NMDA receptors using masked MK801
title_full_unstemmed Cell type-specific pharmacology of NMDA receptors using masked MK801
title_short Cell type-specific pharmacology of NMDA receptors using masked MK801
title_sort cell type-specific pharmacology of nmda receptors using masked mk801
topic Biochemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4594264/
https://www.ncbi.nlm.nih.gov/pubmed/26359633
http://dx.doi.org/10.7554/eLife.10206
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AT sternsonscottm celltypespecificpharmacologyofnmdareceptorsusingmaskedmk801

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