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Domain III S4 in closed-state fast inactivation: Insights from a periodic paralysis mutation
Heterologous expression of sodium channel mutations in hypokalemic periodic paralysis reveals 2 variants on channel dysfunction. Charge-reducing mutations of voltage sensing S4 arginine residues alter channel gating as typically studied with expression in mammalian cells. These mutations also produc...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Taylor & Francis
2014
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4594372/ https://www.ncbi.nlm.nih.gov/pubmed/25483590 http://dx.doi.org/10.4161/19336950.2014.958924 |