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Lipid disequilibrium in biological membranes, a possible pathway to neurodegeneration

We recently reported that knocking down the enzyme phosphatidylserine decarboxylase, which synthesizes the phospholipid phosphatidylethanolamine (PE) in mitochondria, perturbs the homeostasis of the human Parkinson disease (PD) protein α-synuclein (expressed in yeast or worms). In yeast, low PE in t...

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Detalles Bibliográficos
Autor principal: Witt, Stephan N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4594524/
https://www.ncbi.nlm.nih.gov/pubmed/26480301
http://dx.doi.org/10.4161/19420889.2014.993266