Cargando…

Lipid disequilibrium in biological membranes, a possible pathway to neurodegeneration

We recently reported that knocking down the enzyme phosphatidylserine decarboxylase, which synthesizes the phospholipid phosphatidylethanolamine (PE) in mitochondria, perturbs the homeostasis of the human Parkinson disease (PD) protein α-synuclein (expressed in yeast or worms). In yeast, low PE in t...

Descripción completa

Detalles Bibliográficos
Autor principal:	Witt, Stephan N.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2015
Materias:	Article Addendum
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4594524/ https://www.ncbi.nlm.nih.gov/pubmed/26480301 http://dx.doi.org/10.4161/19420889.2014.993266

Ejemplares similares

Mitochondrial dysfunction and defects in lipid homeostasis as therapeutic targets in neurodegeneration with brain iron accumulation
por: Kinghorn, Kerri J., et al.
Publicado: (2016)

Senataxin protects the genome: Implications for neurodegeneration and other abnormalities
por: Lavin, Martin F., et al.
Publicado: (2013)

Addendum: An Optimised Dual Extraction Method for the Simultaneous and Accurate Analysis of Polar Metabolites and Lipids Carried out on Single Biological Samples. Metabolites 2020, 10, 338
por: Villaret-Cazadamont, Joran, et al.
Publicado: (2020)

Possible function of VIPP1 in thylakoids: Protection but not formation?
por: Zhang, Lingang, et al.
Publicado: (2013)

Vesicular trafficking in characean green algae and the possible involvement of a VAMP72-family protein
por: Hoepflinger, Marion C, et al.
Publicado: (2014)

Lysosomal membrane protein SIDT2 mediates the direct uptake of DNA by lysosomes
por: Aizawa, Shu, et al.
Publicado: (2016)

Addendum: Unravelling actionable biology using transcriptomic data to integrate mitotic index and Ki-67 in the management of lung neuroendocrine tumors
por: Manem, Venkata S.K., et al.
Publicado: (2022)

Proposed mechanism for the initiation of transposable element silencing by the RDR6-directed DNA methylation pathway
por: Panda, Kaushik, et al.
Publicado: (2013)

Global Science Meets Ethnic Diversity: Ian McGonigle interviews GenomeAsia100k Scientific Chairman Stephan Schuster–ADDENDUM
por: McGonigle, Ian, et al.
Publicado: (2019)

New insights into the pathophysiology of the tuberous sclerosis complex: Crosstalk of mTOR- and hippo-YAP pathways in cell growth
por: Dill, Patricia E, et al.
Publicado: (2015)

Addendum: Genome-wide association study of depression phenotypes in UK Biobank identifies variants in excitatory synaptic pathways
por: Howard, David M., et al.
Publicado: (2018)

Engineering NOG-pathway in Escherichia coli for poly-(3-hydroxybutyrate) production from low cost carbon sources
por: Zheng, Yangyang, et al.
Publicado: (2018)

Addendum: Kotál et al. Ixodes ricinus Salivary Serpin Iripin-8 Inhibits the Intrinsic Pathway of Coagulation and Complement. Int. J. Mol. Sci. 2021, 22, 9480
por: Kotál, Jan, et al.
Publicado: (2021)

Addendum: Bedoya-Pérez, L.P. et al. Role of UPR Pathway in Defense Response of Aedes aegypti against Cry11Aa Toxin from Bacillus thuringiensis. Int. J. Mol. Sci. 2013, 14, 8467–8478
por: Bedoya-Pérez, Leidy P., et al.
Publicado: (2016)

Addendum: Thomas et al. Retinal Ganglion Cells Die by Necroptotic Mechanisms in a Site-Specific Manner in a Rat Blunt Ocular Injury Model. Cells 2019, 8, 1517
por: Thomas, Chloe N., et al.
Publicado: (2021)

Possible role of IRTKS in Tks5-driven osteoclast fusion
por: Oikawa, Tsukasa, et al.
Publicado: (2012)

Addendum: Standardized diagnostic algorithm for spitzoid lesions aids clinical decision-making and management: a case series from a Swiss reference center
por: Hilbers, Marie-Luise, et al.
Publicado: (2022)

Neurodevelopmental models of transcription factor 4 deficiency converge on a common ion channel as a potential therapeutic target for Pitt Hopkins syndrome
por: Rannals, Matthew D., et al.
Publicado: (2016)

Effectiveness of non-medical health worker-led counselling on psychological distress: a randomized controlled trial in rural Nepal – ADDENDUM
por: Markkula, N., et al.
Publicado: (2019)

Interplay between the Genetics of Personality Traits, severe Psychiatric Disorders, and COVID-19 Host Genetics in the Susceptibility to SARS-CoV-2 Infection - ADDENDUM
por: Heilbronner, Urs, et al.
Publicado: (2021)

The type three secreted effector SipC regulates the trafficking of PERP during Salmonella infection
por: Hallstrom, Kelly N., et al.
Publicado: (2016)

Gut microbiome in multiple sclerosis: The players involved and the roles they play
por: Shahi, Shailesh K., et al.
Publicado: (2017)

Optimization of saccharification potential of recombinant xylanase from Bacillus licheniformis
por: Aftab, Muhammad N., et al.
Publicado: (2017)

Addendum: Melatonin increases overall survival of prostate cancer patients with poor prognosis after combined hormone radiation treatment
por: Zharinov, Gennady M., et al.
Publicado: (2023)

Dissemination and implementation science resources, training, and scientific activities provided through CTSA programs nationally: Opportunities to advance D&I research and training capacity – ADDENDUM
por: Shelton, Rachel C., et al.
Publicado: (2022)

Redox regulation of phototactic migration in the green alga Chlamydomonas reinhardtii and its possible application
por: Mochiji, Shota, et al.
Publicado: (2012)

Addendum: Sustained response of three pediatric BRAF(V600E) mutated high-grade gliomas to combined BRAF and MEK inhibitor therapy
por: Toll, Stephanie A., et al.
Publicado: (2023)

Addendum: Transcriptomics and proteomics reveal two waves of translational repression during the maturation of malaria parasite sporozoites
por: Lindner, Scott E., et al.
Publicado: (2022)

Shiga toxin 2a and Enteroaggregative Escherichia coli – a deadly combination
por: Boisen, Nadia, et al.
Publicado: (2015)

A commentary on the utility of a new L-DOPA-responsive dystonia mouse model
por: Rose, Samuel J., et al.
Publicado: (2015)

Addendum: The observation of vibrating pear-shapes in radon nuclei
por: Butler, P. A., et al.
Publicado: (2020)

Clozapine in a patient with treatment-resistant schizophrenia and hypertrophic cardiomyopathy: a case report — ADDENDUM
por: Sanchez, Asiel Yair Adan, et al.
Publicado: (2019)

Editorial Expression of Concern: IRE1a constitutes a negative feedback loop with BMP2 and acts as a novel mediator in modulating osteogenic differentiation
por: Guo, F. J., et al.
Publicado: (2018)

Loss of the tumor suppressor SMARCA4 in small cell carcinoma of the ovary, hypercalcemic type (SCCOHT)
por: Ramos, Pilar, et al.
Publicado: (2014)

Evolutionary developmental biology in cycad phenology
por: Gorelick, Root, et al.
Publicado: (2012)

The biocommunication method: On the road to an integrative biology
por: Witzany, Guenther
Publicado: (2016)

Staufen1s role as a splicing factor and a disease modifier in Myotonic Dystrophy Type I
por: Bondy-Chorney, Emma, et al.
Publicado: (2016)

Dystrophin: The dead calm of a dogma
por: Górecki, Dariusz C.
Publicado: (2016)

Huntington's disease is a multi-system disorder
por: Mielcarek, Michal
Publicado: (2015)

Addendum: Effect of acetylcholinesterase inhibitors on post-surgical complications and mortality following a hip fracture: a cohort study
por: Tamimi, I., et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_itg1ram696nlvjd6ueddd9bmed