Cargando…

Downregulation of ASPP2 in pancreatic cancer cells contributes to increased resistance to gemcitabine through autophagy activation

BACKGROUND: Apoptosis-stimulating of p53 protein 2 (ASPP2) is one of the ASPP family members and it has been reported to be associated with human cancer. However, the role of it in pancreatic cancer is still not clear. METHODS: We analyzed the expression level of ASPP2 in cancer tissue samples with...

Descripción completa

Detalles Bibliográficos
Autores principales:	Song, Bin, Bian, Qi, Zhang, Yi-Jie, Shao, Cheng-Hao, Li, Gang, Liu, An-An, Jing, Wei, Liu, Rui, Zhou, Ying-Qi, Jin, Gang, Hu, Xian-Gui
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2015
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4594892/ https://www.ncbi.nlm.nih.gov/pubmed/26438046 http://dx.doi.org/10.1186/s12943-015-0447-5

Ejemplares similares

Downregulation of ASPP2 improves hepatocellular carcinoma cells survival via promoting BECN1-dependent autophagy initiation
por: Chen, Rui, et al.
Publicado: (2016)

Ulinastatin Reduces the Resistance of Liver Cancer Cells to Epirubicin by Inhibiting Autophagy
por: Song, Bin, et al.
Publicado: (2015)

ASPP2 promotes cell apoptosis in cervical cancer through inhibiting autophagy
por: Jiang, Feiyun, et al.
Publicado: (2022)

Girdin Knockdown Increases Gemcitabine Chemosensitivity to Pancreatic Cancer by Modulating Autophagy
por: Wang, Sheng, et al.
Publicado: (2021)

ASPP2 Plays a Dual Role in gp120-Induced Autophagy and Apoptosis of Neuroblastoma Cells
por: Liu, Zhiying, et al.
Publicado: (2017)

ASPP2 inhibits tumor growth by repressing the mevalonate pathway in hepatocellular carcinoma
por: Liang, Beibei, et al.
Publicado: (2019)

Overexpression of iASPP is required for autophagy in response to oxidative stress in choriocarcinoma
por: Chan, Ka-Kui, et al.
Publicado: (2019)

EGR-1/ASPP1 inter-regulatory loop promotes apoptosis by inhibiting cyto-protective autophagy
por: Zhao, Kunming, et al.
Publicado: (2017)

AB97. MicroRNA124 regulate cell growth of prostate cancer cells by targeting iASPP
por: Chen, Jun, et al.
Publicado: (2014)

PRRX1/FOXM1 reduces gemcitabin-induced cytotoxicity by regulating autophagy in bladder cancer
por: Huang, Xixi, et al.
Publicado: (2022)

Downregulation of miR-183 inhibits the growth of PANC-1 pancreatic cancer cells in vitro and in vivo, and increases chemosensitivity to 5-fluorouracil and gemcitabine
por: Yang, Xiaoping, et al.
Publicado: (2019)

Molecular interactions of ASPP1 and ASPP2 with the p53 protein family and the apoptotic promoters PUMA and Bax
por: Patel, Seema, et al.
Publicado: (2008)

TNNC1 Reduced Gemcitabine Sensitivity of Nonsmall-Cell Lung Cancer by Increasing Autophagy
por: Ye, Xian, et al.
Publicado: (2020)

Nanoparticle-Mediated Therapy with miR-198 Sensitizes Pancreatic Cancer to Gemcitabine Treatment through Downregulation of VCP-Mediated Autophagy
por: Marin-Muller, Christian, et al.
Publicado: (2023)

MicroRNA-124 Regulates the Proliferation of Colorectal Cancer Cells by Targeting iASPP
por: Liu, Kuijie, et al.
Publicado: (2013)

iASPP contributes to cell cortex rigidity, mitotic cell rounding, and spindle positioning
por: Mangon, Aurélie, et al.
Publicado: (2021)

iASPP facilitates tumor growth by promoting mTOR-dependent autophagy in human non-small-cell lung cancer
por: Xue, Yijun, et al.
Publicado: (2017)

Downregulation of ASPP2 promotes gallbladder cancer metastasis and macrophage recruitment via aPKC-ι/GLI1 pathway
por: Tian, Li, et al.
Publicado: (2018)

ASPP1 and ASPP2 bind active RAS, potentiate RAS signalling and enhance p53 activity in cancer cells
por: Wang, Y, et al.
Publicado: (2013)

p53 inhibitor iASPP is an unexpected suppressor of KRAS and inflammation-driven pancreatic cancer
por: Miller, Paul, et al.
Publicado: (2023)

ASPP2 Is Phosphorylated by CDK1 during Mitosis and Required for Pancreatic Cancer Cell Proliferation
por: Xiao, Yi, et al.
Publicado: (2023)

Downregulation of Inhibition of Apoptosis-Stimulating Protein of p53 (iASPP) Suppresses Cisplatin-Resistant Gastric Carcinoma In Vitro
por: Yu, Jianyong, et al.
Publicado: (2017)

Wogonin increases gemcitabine sensitivity in pancreatic cancer by inhibiting Akt pathway
por: Zhang, Tianli, et al.
Publicado: (2022)

Curcumin enhances anti-cancer efficacy of either gemcitabine or docetaxel on pancreatic cancer cells
por: Liu, Pan, et al.
Publicado: (2020)

Targeting interleukin-17 receptor B enhances gemcitabine sensitivity through downregulation of mucins in pancreatic cancer
por: Tsai, Lung-Hung, et al.
Publicado: (2020)

Blockade of autophagy reduces pancreatic cancer stem cell activity and potentiates the tumoricidal effect of gemcitabine
por: Yang, Ming-Chen, et al.
Publicado: (2015)

Sox2 function as a negative regulator to control HAMP expression
por: Song, Bin, et al.
Publicado: (2015)

ASPP2 Inhibits the Profibrotic Effects of Transforming Growth Factor-β1 in Hepatic Stellate Cells by Reducing Autophagy
por: Lin, Minghua, et al.
Publicado: (2017)

Autophagy Inhibition Contributes to Apoptosis of PLK4 Downregulation-induced Dormant Cells in Colorectal Cancer
por: Tian, Xiangdong, et al.
Publicado: (2023)

Incidence of bifid pancreatic duct in pancreaticoduodenectomy and its impact on clinically relevant postoperative pancreatic fistula
por: Ouyang, Liu, et al.
Publicado: (2022)

FHL2 interacts with iASPP and impacts the biological functions of leukemia cells
por: Lu, Wenting, et al.
Publicado: (2017)

ASPP: a new family of oncogenes and tumour suppressor genes
por: Sullivan, A, et al.
Publicado: (2007)

Nucleostemin and ASPP2 expression is correlated with pituitary adenoma proliferation
por: MA, LIN, et al.
Publicado: (2013)

Nuclear iASPP may facilitate prostate cancer progression
por: Morris, E V, et al.
Publicado: (2014)

ASPP2 Is a Novel Pan-Ras Nanocluster Scaffold
por: Posada, Itziar M. D., et al.
Publicado: (2016)

Regulation of immunological tolerance by the p53-inhibitor iASPP
por: Akama-Garren, Elliot H., et al.
Publicado: (2023)

iASPP regulates neurite development by interacting with Spectrin proteins
por: Wang, Junhao, et al.
Publicado: (2023)

Autophagy downregulation contributes to insulin resistance mediated injury in insulin receptor knockout podocytes in vitro
por: Xu, Ying, et al.
Publicado: (2016)

Resveratrol-Induced Downregulation of NAF-1 Enhances the Sensitivity of Pancreatic Cancer Cells to Gemcitabine via the ROS/Nrf2 Signaling Pathways
por: Cheng, Liang, et al.
Publicado: (2018)

Genome-Wide CRISPR Screening Identifies DCK and CCNL1 as Genes That Contribute to Gemcitabine Resistance in Pancreatic Cancer
por: Yang, Hai, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_3fj6tngqnmkectlng4e9ho6a2b