Moderate calorie restriction to achieve normal weight reverses β-cell dysfunction in diet-induced obese mice: involvement of autophagy

BACKGROUND: Severe calorie restriction (CR) is shown to improve or even reverse β-cell dysfunction in patients with obesity and type 2 diabetes mellitus. However, whether mild to moderate CR can reverse β-cell dysfunction induced by obesity and the underlying mechanism remain unclear. Autophagy play...

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Detalles Bibliográficos
Autores principales: Gao, Xiuying, Yan, Dien, Zhao, Yinan, Tao, Hong, Zhou, Yingsheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4595003/
https://www.ncbi.nlm.nih.gov/pubmed/26445593
http://dx.doi.org/10.1186/s12986-015-0028-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4595003/
https://www.ncbi.nlm.nih.gov/pubmed/26445593
http://dx.doi.org/10.1186/s12986-015-0028-z

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