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Proteolysis of MDA5 and IPS-1 is not required for inhibition of the type I IFN response by poliovirus
BACKGROUND: The type I interferon (IFN) response is a critical component of the innate immune response to infection by RNA viruses and is initiated via recognition of viral nucleic acids by RIG-like receptors (RLR). Engagement of these receptors in the cytoplasm initiates a signal transduction pathw...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2015
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4595118/ https://www.ncbi.nlm.nih.gov/pubmed/26437794 http://dx.doi.org/10.1186/s12985-015-0393-2 |