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Proteolysis of MDA5 and IPS-1 is not required for inhibition of the type I IFN response by poliovirus

BACKGROUND: The type I interferon (IFN) response is a critical component of the innate immune response to infection by RNA viruses and is initiated via recognition of viral nucleic acids by RIG-like receptors (RLR). Engagement of these receptors in the cytoplasm initiates a signal transduction pathw...

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Detalles Bibliográficos
Autores principales:	Kotla, Swathi, Gustin, Kurt E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2015
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4595118/ https://www.ncbi.nlm.nih.gov/pubmed/26437794 http://dx.doi.org/10.1186/s12985-015-0393-2

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