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Systematic Characteristic Exploration of the Chimeras Generated in Multiple Displacement Amplification through Next Generation Sequencing Data Reanalysis

BACKGROUND: The chimeric sequences produced by phi29 DNA polymerase, which are named as chimeras, influence the performance of the multiple displacement amplification (MDA) and also increase the difficulty of sequence data process. Despite several articles have reported the existence of chimeric seq...

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Detalles Bibliográficos
Autores principales: Tu, Jing, Guo, Jing, Li, Junji, Gao, Shen, Yao, Bei, Lu, Zuhong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4595205/
https://www.ncbi.nlm.nih.gov/pubmed/26440104
http://dx.doi.org/10.1371/journal.pone.0139857