A Group of ent-Kaurane Diterpenoids Inhibit Hedgehog Signaling and Induce Cilia Elongation

The Hedgehog (Hh) signaling pathway plays important roles in the tumorigenesis of multiple cancers and is a key target for drug discovery. In a screen of natural products extracted from Chinese herbs, we identified eight ent-Kaurane diterpenoids and two triterpene dilactones as novel Hh pathway anta...

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Detalles Bibliográficos
Autores principales: Jiang, Shiyou, Du, Jiacheng, Kong, Qinghua, Li, Chaocui, Li, Yan, Sun, Handong, Pu, Jianxin, Mao, Bingyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4595341/
https://www.ncbi.nlm.nih.gov/pubmed/26439749
http://dx.doi.org/10.1371/journal.pone.0139830

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4595341/
https://www.ncbi.nlm.nih.gov/pubmed/26439749
http://dx.doi.org/10.1371/journal.pone.0139830

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