Endogenous Formaldehyde Is a Hematopoietic Stem Cell Genotoxin and Metabolic Carcinogen

Endogenous formaldehyde is produced by numerous biochemical pathways fundamental to life, and it can crosslink both DNA and proteins. However, the consequences of its accumulation are unclear. Here we show that endogenous formaldehyde is removed by the enzyme alcohol dehydrogenase 5 (ADH5/GSNOR), an...

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Detalles Bibliográficos
Autores principales: Pontel, Lucas B., Rosado, Ivan V., Burgos-Barragan, Guillermo, Garaycoechea, Juan I., Yu, Rui, Arends, Mark J., Chandrasekaran, Gayathri, Broecker, Verena, Wei, Wei, Liu, Limin, Swenberg, James A., Crossan, Gerry P., Patel, Ketan J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4595711/
https://www.ncbi.nlm.nih.gov/pubmed/26412304
http://dx.doi.org/10.1016/j.molcel.2015.08.020

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4595711/
https://www.ncbi.nlm.nih.gov/pubmed/26412304
http://dx.doi.org/10.1016/j.molcel.2015.08.020

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