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Endogenous Formaldehyde Is a Hematopoietic Stem Cell Genotoxin and Metabolic Carcinogen
Endogenous formaldehyde is produced by numerous biochemical pathways fundamental to life, and it can crosslink both DNA and proteins. However, the consequences of its accumulation are unclear. Here we show that endogenous formaldehyde is removed by the enzyme alcohol dehydrogenase 5 (ADH5/GSNOR), an...
Autores principales: | Pontel, Lucas B., Rosado, Ivan V., Burgos-Barragan, Guillermo, Garaycoechea, Juan I., Yu, Rui, Arends, Mark J., Chandrasekaran, Gayathri, Broecker, Verena, Wei, Wei, Liu, Limin, Swenberg, James A., Crossan, Gerry P., Patel, Ketan J. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cell Press
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4595711/ https://www.ncbi.nlm.nih.gov/pubmed/26412304 http://dx.doi.org/10.1016/j.molcel.2015.08.020 |
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