Enhancing S-adenosyl-methionine catabolism extends Drosophila lifespan

Methionine restriction extends the lifespan of various model organisms. Limiting S-adenosyl-methionine (SAM) synthesis, the first metabolic reaction of dietary methionine, extends longevity in Caenorhabditis elegans but accelerates pathology in mammals. Here, we show that, as an alternative to inhib...

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Detalles Bibliográficos
Autores principales: Obata, Fumiaki, Miura, Masayuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4595730/
https://www.ncbi.nlm.nih.gov/pubmed/26383889
http://dx.doi.org/10.1038/ncomms9332

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4595730/
https://www.ncbi.nlm.nih.gov/pubmed/26383889
http://dx.doi.org/10.1038/ncomms9332

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