An improved chloride-conducting channelrhodopsin for light-induced inhibition of neuronal activity in vivo

Channelrhodopsins are light-gated cation channels that have been widely used for optogenetic stimulation of electrically excitable cells. Replacement of a glutamic acid in the central gate with a positively charged amino acid residue reverses the ion selectivity and produces chloride-conducting ChRs...

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Detalles Bibliográficos
Autores principales: Wietek, Jonas, Beltramo, Riccardo, Scanziani, Massimo, Hegemann, Peter, Oertner, Thomas G., Simon Wiegert, J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4595828/
https://www.ncbi.nlm.nih.gov/pubmed/26443033
http://dx.doi.org/10.1038/srep14807

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4595828/
https://www.ncbi.nlm.nih.gov/pubmed/26443033
http://dx.doi.org/10.1038/srep14807

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