Dissolution Rate Enhancement, Design and Development of Buccal Drug Delivery of Darifenacin Hydroxypropyl β-Cyclodextrin Inclusion Complexes

Darifenacin is a urinary antispasmodic. The oral absorption of darifenacin is poor due to its low solubility and poor bioavailability (15–19%). Darifenacin was complexed with hydroxylropyl beta-cyclodextrin (Hpβ-CD). The best results were obtained with the coevaporation that interacts in a 1 : 1 dru...

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Detalles Bibliográficos
Autores principales: Jagdale, Swati C., Mohanty, Prachyasuman, Chabukswar, Aniruddha R., Kuchekar, Bhanudas S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4595963/
https://www.ncbi.nlm.nih.gov/pubmed/26556003
http://dx.doi.org/10.1155/2013/983702

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4595963/
https://www.ncbi.nlm.nih.gov/pubmed/26556003
http://dx.doi.org/10.1155/2013/983702

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