The molecular chaperone Brichos breaks the catalytic cycle that generates toxic Aβ oligomers

Alzheimer’s disease is an increasingly prevalent neurodegenerative disorder whose pathogenesis has been associated with aggregation of the amyloid-β peptide (Aβ42). Recent studies have revealed that once Aβ42 fibrils are generated, their surfaces strongly catalyse the formation of neurotoxic oligome...

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Detalles Bibliográficos
Autores principales: Cohen, Samuel I. A., Arosio, Paolo, Presto, Jenny, Kurudenkandy, Firoz Roshan, Biverstal, Henrik, Dolfe, Lisa, Dunning, Christopher, Yang, Xiaoting, Frohm, Birgitta, Vendruscolo, Michele, Johansson, Jan, Dobson, Christopher M., Fisahn, André, Knowles, Tuomas P. J., Linse, Sara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4595974/
https://www.ncbi.nlm.nih.gov/pubmed/25686087
http://dx.doi.org/10.1038/nsmb.2971

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4595974/
https://www.ncbi.nlm.nih.gov/pubmed/25686087
http://dx.doi.org/10.1038/nsmb.2971

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