Selective Effects of PDE10A Inhibitors on Striatopallidal Neurons Require Phosphatase Inhibition by DARPP-321,2,3

Type 10A phosphodiesterase (PDE10A) is highly expressed in the striatum, in striatonigral and striatopallidal medium-sized spiny neurons (MSNs), which express D(1) and D(2) dopamine receptors, respectively. PDE10A inhibitors have pharmacological and behavioral effects suggesting an antipsychotic pro...

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Detalles Bibliográficos
Autores principales: Polito, Marina, Guiot, Elvire, Gangarossa, Giuseppe, Longueville, Sophie, Doulazmi, Mohamed, Valjent, Emmanuel, Hervé, Denis, Girault, Jean-Antoine, Paupardin-Tritsch, Danièle, Castro, Liliana R. V., Vincent, Pierre
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Society for Neuroscience 2015
Materias:
New Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4596023/
https://www.ncbi.nlm.nih.gov/pubmed/26465004
http://dx.doi.org/10.1523/ENEURO.0060-15.2015

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4596023/
https://www.ncbi.nlm.nih.gov/pubmed/26465004
http://dx.doi.org/10.1523/ENEURO.0060-15.2015

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