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Individual Cytokines Modulate the Neurological Symptoms of ATM Deficiency in a Region Specific Manner1,2,3

Ataxia-telangiectasia (A-T) is a multisystemic neurodegenerative disease of childhood caused by the absence of functional ATM (A-T mutated) protein. The cerebellar cortex has the most obvious neuropathology, yet cells in other brain regions are also abnormal. A-T mouse models have been produced that...

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Detalles Bibliográficos
Autores principales: Hui, Chin Wai, Herrup, Karl
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Society for Neuroscience 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4596028/
https://www.ncbi.nlm.nih.gov/pubmed/26465009
http://dx.doi.org/10.1523/ENEURO.0032-15.2015