LRP1 Downregulates the Alzheimer’s β-Secretase BACE1 by Modulating Its Intraneuronal Trafficking1,2,3

The β-secretase called BACE1 is a membrane-associated protease that initiates the generation of amyloid β-protein (Aβ), a key event in Alzheimer’s disease (AD). However, the mechanism of intraneuronal regulation of BACE1 is poorly understood. Here, we present evidence that low-density lipoprotein re...

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Detalles Bibliográficos
Autores principales: Tanokashira, Daisuke, Motoki, Kazumi, Minegishi, Seiji, Hosaka, Ai, Mamada, Naomi, Tamaoka, Akira, Okada, Takashi, Lakshmana, Madepalli K., Araki, Wataru
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Society for Neuroscience 2015
Materias:
New Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4596091/
https://www.ncbi.nlm.nih.gov/pubmed/26464978
http://dx.doi.org/10.1523/ENEURO.0006-15.2015

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4596091/
https://www.ncbi.nlm.nih.gov/pubmed/26464978
http://dx.doi.org/10.1523/ENEURO.0006-15.2015

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