Synaptotagmin-1 binds to PIP(2)-containing membrane but not to SNAREs at physiological ionic strength

Ca(2+)-sensor synaptotagmin-1 is thought to trigger membrane fusion by binding to acidic membrane lipids and SNARE proteins. Previous work has shown that binding is mediated by electrostatic interactions that are sensitive to the ionic environment. However, the influence of divalent or polyvalent io...

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Detalles Bibliográficos
Autores principales: Park, Yongsoo, Seo, Jong Bae, Fraind, Alicia, Pérez-Lara, Angel, Yavuz, Halenur, Han, Kyungreem, Jung, Seung-Ryoung, Kattan, Iman, Walla, Peter Jomo, Choi, MooYoung, Cafiso, David S., Koh, Duk-Su, Jahn, Reinhard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4596797/
https://www.ncbi.nlm.nih.gov/pubmed/26389740
http://dx.doi.org/10.1038/nsmb.3097

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4596797/
https://www.ncbi.nlm.nih.gov/pubmed/26389740
http://dx.doi.org/10.1038/nsmb.3097

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