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Synaptotagmin-1 binds to PIP(2)-containing membrane but not to SNAREs at physiological ionic strength
Ca(2+)-sensor synaptotagmin-1 is thought to trigger membrane fusion by binding to acidic membrane lipids and SNARE proteins. Previous work has shown that binding is mediated by electrostatic interactions that are sensitive to the ionic environment. However, the influence of divalent or polyvalent io...
| Autores principales: | , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4596797/ https://www.ncbi.nlm.nih.gov/pubmed/26389740 http://dx.doi.org/10.1038/nsmb.3097 |