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Affinity Inequality among Serum Antibodies That Originate in Lymphoid Germinal Centers

Upon natural infection with pathogens or vaccination, antibodies are produced by a process called affinity maturation. As affinity maturation ensues, average affinity values between an antibody and ligand increase with time. Purified antibodies isolated from serum are invariably heterogeneous with r...

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Detalles Bibliográficos
Autores principales: Kang, Myungsun, Eisen, Timothy J., Eisen, Ellen A., Chakraborty, Arup K., Eisen, Herman N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4596808/
https://www.ncbi.nlm.nih.gov/pubmed/26444899
http://dx.doi.org/10.1371/journal.pone.0139222