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Current ADC Linker Chemistry

The list of ADCs in the clinic continues to grow, bolstered by the success of first two marketed ADCs: ADCETRIS® and Kadcyla®. Currently, there are 40 ADCs in various phases of clinical development. However, only 34 of these have published their structures. Of the 34 disclosed structures, 24 of them...

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Detalles Bibliográficos
Autores principales: Jain, Nareshkumar, Smith, Sean W., Ghone, Sanjeevani, Tomczuk, Bruce
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4596905/
https://www.ncbi.nlm.nih.gov/pubmed/25759187
http://dx.doi.org/10.1007/s11095-015-1657-7