N-glycan PK Profiling Using a High Sensitivity nanoLCMS Work-Flow with Heavy Stable Isotope Labeled Internal Standard and Application to a Preclinical Study of an IgG1 Biopharmaceutical

PURPOSE: In this study an innovative, highly sensitive work-flow is presented that allows the analysis of a possible influence of individual glyco-variants on pharmacokinetics already during pre-clinical development. Possible effects on the pharmacokinetics caused by glyco-variants have been subject...

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Detalles Bibliográficos
Autores principales: Higel, Fabian, Seidl, Andreas, Demelbauer, Uwe, Viertlboeck-Schudy, Margot, Koppenburg, Vera, Kronthaler, Ulrich, Sörgel, Fritz, Frieß, Wolfgang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4596906/
https://www.ncbi.nlm.nih.gov/pubmed/26017302
http://dx.doi.org/10.1007/s11095-015-1724-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4596906/
https://www.ncbi.nlm.nih.gov/pubmed/26017302
http://dx.doi.org/10.1007/s11095-015-1724-0

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