Highly Efficient CYP167A1 (EpoK) dependent Epothilone B Formation and Production of 7-Ketone Epothilone D as a New Epothilone Derivative

Since their discovery in the soil bacterium Sorangium cellulosum, epothilones have emerged as a valuable substance class with promising anti-tumor activity. Because of their benefits in the treatment of cancer and neurodegenerative diseases, epothilones are targets for drug design and pharmaceutical...

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Detalles Bibliográficos
Autores principales: Kern, Fredy, Dier, Tobias K. F., Khatri, Yogan, Ewen, Kerstin M., Jacquot, Jean-Pierre, Volmer, Dietrich A., Bernhardt, Rita
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4597204/
https://www.ncbi.nlm.nih.gov/pubmed/26445909
http://dx.doi.org/10.1038/srep14881

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4597204/
https://www.ncbi.nlm.nih.gov/pubmed/26445909
http://dx.doi.org/10.1038/srep14881

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