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Detection of novel CYP11A1-derived secosteroids in the human epidermis and serum and pig adrenal gland

To investigate whether novel pathways of vitamin D3 (D3) and 7-dehydrocholesterol (7DHC) metabolism initiated by CYP11A1 and previously characterized in vitro, occur in vivo, we analyzed samples of human serum and epidermis, and pig adrenals for the presence of intermediates and products of these pa...

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Detalles Bibliográficos
Autores principales: Slominski, Andrzej T., Kim, Tae-Kang, Li, Wei, Postlethwaite, Arnold, Tieu, Elaine W., Tang, Edith K. Y., Tuckey, Robert C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4597207/
https://www.ncbi.nlm.nih.gov/pubmed/26445902
http://dx.doi.org/10.1038/srep14875