Synthesis of an arrayed sgRNA library targeting the human genome

Clustered regularly interspaced short palindromic repeats (CRISPR) in conjunction with CRISPR-associated proteins (Cas) can be employed to introduce double stand breaks into mammalian genomes at user-defined loci. The endonuclease activity of the Cas complex can be targeted to a specific genomic reg...

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Detalles Bibliográficos
Autores principales: Schmidt, Tobias, Schmid-Burgk, Jonathan L., Hornung, Veit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4597219/
https://www.ncbi.nlm.nih.gov/pubmed/26446710
http://dx.doi.org/10.1038/srep14987

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4597219/
https://www.ncbi.nlm.nih.gov/pubmed/26446710
http://dx.doi.org/10.1038/srep14987

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