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RhoA Ambivalently Controls Prominent Myofibroblast Characteritics by Involving Distinct Signaling Routes

INTRODUCTION: RhoA has been shown to be beneficial in cardiac disease models when overexpressed in cardiomyocytes, whereas its role in cardiac fibroblasts (CF) is still poorly understood. During cardiac remodeling CF undergo a transition towards a myofibroblast phenotype thereby showing an increased...

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Detalles Bibliográficos
Autores principales: Jatho, Aline, Hartmann, Svenja, Kittana, Naim, Mügge, Felicitas, Wuertz, Christina M., Tiburcy, Malte, Zimmermann, Wolfram-Hubertus, Katschinski, Dörthe M., Lutz, Susanne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4598021/
https://www.ncbi.nlm.nih.gov/pubmed/26448568
http://dx.doi.org/10.1371/journal.pone.0137519