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Generation of New Hairless Alleles by Genomic Engineering at the Hairless Locus in Drosophila melanogaster
Hairless (H) is the major antagonist within the Notch signalling pathway of Drosophila melanogaster. By binding to Suppressor of Hairless [Su(H)] and two co-repressors, H induces silencing of Notch target genes in the absence of Notch signals. We have applied genomic engineering to create several ne...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4598140/ https://www.ncbi.nlm.nih.gov/pubmed/26448463 http://dx.doi.org/10.1371/journal.pone.0140007 |