Deletion of Stat3 enhances myeloid cell expansion and increases the severity of myeloproliferative neoplasms in Jak2V617F knock-in mice

The JAK2V617F mutation commonly found in myeloproliferative neoplasms (MPNs) induces constitutive phosphorylation/activation of the signal transducer and activator of transcription 3 (Stat3). However, the contribution of Stat3 in MPN evoked by JAK2V617F remains unknown. To determine the role of Stat...

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Detalles Bibliográficos
Autores principales: Yan, Dongqing, Jobe, Fatoumata, Hutchison, Robert E., Mohi, Golam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4598256/
https://www.ncbi.nlm.nih.gov/pubmed/26044284
http://dx.doi.org/10.1038/leu.2015.116

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4598256/
https://www.ncbi.nlm.nih.gov/pubmed/26044284
http://dx.doi.org/10.1038/leu.2015.116

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