CD47 Blockade Triggers T cell-mediated Destruction of Immunogenic Tumors

Macrophage phagocytosis of tumor cells mediated by CD47-specific blocking antibodies has been proposed to be the major effector mechanism in xenograft models. Using syngeneic immunocompetent tumor models, we reveal that in the therapeutic effects of CD47 blockade depend on dendritic cell (DC) but no...

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Detalles Bibliográficos
Autores principales: Liu, Xiaojuan, Pu, Yang, Cron, Kyle, Deng, Liufu, Kline, Justin, Frazier, William A., Xu, Hairong, Peng, Hua, Fu, Yang-Xin, Xu, Meng Michelle
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4598283/
https://www.ncbi.nlm.nih.gov/pubmed/26322579
http://dx.doi.org/10.1038/nm.3931

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4598283/
https://www.ncbi.nlm.nih.gov/pubmed/26322579
http://dx.doi.org/10.1038/nm.3931

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