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Direct quantitative detection of Doc2b-induced hemifusion in optically trapped membranes

Ca(2+)-sensor proteins control the secretion of many neuroendocrine substances. Calcium-secretion coupling may involve several mechanisms. First, Ca(2+)-dependent association of their tandem C2 domains with phosphatidylserine may induce membrane curvature and thereby enhance fusion. Second, their as...

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Detalles Bibliográficos
Autores principales: Brouwer, Ineke, Giniatullina, Asiya, Laurens, Niels, van Weering, Jan R. T., Bald, Dirk, Wuite, Gijs J. L., Groffen, Alexander J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4598560/
https://www.ncbi.nlm.nih.gov/pubmed/26395669
http://dx.doi.org/10.1038/ncomms9387