Metazoan Hsp70-based protein disaggregases: emergence and mechanisms

Proteotoxic stresses and aging cause breakdown of cellular protein homeostasis, allowing misfolded proteins to form aggregates, which dedicated molecular machines have evolved to solubilize. In bacteria, fungi, protozoa and plants protein disaggregation involves an Hsp70•J-protein chaperone system,...

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Detalles Bibliográficos
Autores principales: Nillegoda, Nadinath B., Bukau, Bernd
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2015
Materias:
Molecular Biosciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4598581/
https://www.ncbi.nlm.nih.gov/pubmed/26501065
http://dx.doi.org/10.3389/fmolb.2015.00057

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4598581/
https://www.ncbi.nlm.nih.gov/pubmed/26501065
http://dx.doi.org/10.3389/fmolb.2015.00057

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