Interplay between arginine methylation and ubiquitylation regulates KLF4-mediated genome stability and carcinogenesis

KLF4 is an important regulator of cell-fate decision, including DNA damage response and apoptosis. We identify a novel interplay between protein modifications in regulating KLF4 function. Here we show that arginine methylation of KLF4 by PRMT5 inhibits KLF4 ubiquitylation by VHL and thereby reduces...

Descripción completa

Detalles Bibliográficos
Autores principales: Hu, Dong, Gur, Mert, Zhou, Zhuan, Gamper, Armin, Hung, Mien-Chie, Fujita, Naoya, Lan, Li, Bahar, Ivet, Wan, Yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4598737/
https://www.ncbi.nlm.nih.gov/pubmed/26420673
http://dx.doi.org/10.1038/ncomms9419

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4598737/
https://www.ncbi.nlm.nih.gov/pubmed/26420673
http://dx.doi.org/10.1038/ncomms9419

Ejemplares similares