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Genome Instability in Development and Aging: Insights from Nucleotide Excision Repair in Humans, Mice, and Worms
DNA damage causally contributes to aging and cancer. Congenital defects in nucleotide excision repair (NER) lead to distinct cancer-prone and premature aging syndromes. The genetics of NER mutations have provided important insights into the distinct consequences of genome instability. Recent work in...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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MDPI
2015
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4598778/ https://www.ncbi.nlm.nih.gov/pubmed/26287260 http://dx.doi.org/10.3390/biom5031855 |