Discovery of Novel Anti-prion Compounds Using In Silico and In Vitro Approaches

Prion diseases are associated with the conformational conversion of the physiological form of cellular prion protein (PrP(C)) to the pathogenic form, PrP(Sc). Compounds that inhibit this process by blocking conversion to the PrP(Sc) could provide useful anti-prion therapies. However, no suitable dru...

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Detalles Bibliográficos
Autores principales: Hyeon, Jae Wook, Choi, Jiwon, Kim, Su Yeon, Govindaraj, Rajiv Gandhi, Jam Hwang, Kyu, Lee, Yeong Seon, An, Seong Soo A., Lee, Myung Koo, Joung, Jong Young, No, Kyoung Tai, Lee, Jeongmin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4598813/
https://www.ncbi.nlm.nih.gov/pubmed/26449325
http://dx.doi.org/10.1038/srep14944

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4598813/
https://www.ncbi.nlm.nih.gov/pubmed/26449325
http://dx.doi.org/10.1038/srep14944

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