Cargando…

Paradoxical effect of rapamycin on inflammatory stress-induced insulin resistance in vitro and in vivo

Insulin resistance is closely related to inflammatory stress and the mammalian target of rapamycin/S6 kinase (mTOR/S6K) pathway. The present study investigated whether rapamycin, a specific inhibitor of mTOR, ameliorates inflammatory stress-induced insulin resistance in vitro and in vivo. We used tu...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yang, Ping, Zhao, Yunfei, Zhao, Lei, Yuan, Jun, Chen, Yao, Varghese, Zac, Moorhead, John F., Chen, Yaxi, Ruan, Xiong Z.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4598825/ https://www.ncbi.nlm.nih.gov/pubmed/26449763 http://dx.doi.org/10.1038/srep14959

Ejemplares similares

Inflammatory Stress Increases Hepatic CD36 Translational Efficiency via Activation of the mTOR Signalling Pathway
por: Wang, Chuan, et al.
Publicado: (2014)

Inflammatory Stress Sensitizes the Liver to Atorvastatin-Induced Injury in ApoE-/- Mice
por: Wu, Wei, et al.
Publicado: (2016)

The molecular pathogenic role of inflammatory stress in dysregulation of lipid homeostasis and hepatic steatosis
por: Chen, Yaxi, et al.
Publicado: (2014)

Inflammatory stress exacerbates ectopic lipid deposition in C57BL/6J mice
por: Mei, Mei, et al.
Publicado: (2011)

High olive oil diets enhance cervical tumour growth in mice: transcriptome analysis for potential candidate genes and pathways
por: Zhang, Xiaoyu, et al.
Publicado: (2019)

Enhanced SCAP Glycosylation by Inflammation Induces Macrophage Foam Cell Formation
por: Zhou, Chao, et al.
Publicado: (2013)

Chronic inflammation aggravates metabolic disorders of hepatic fatty acids in high-fat diet-induced obese mice
por: Zhao, Lei, et al.
Publicado: (2015)

Cholesterol sensor SCAP contributes to sorafenib resistance by regulating autophagy in hepatocellular carcinoma
por: Li, Danyang, et al.
Publicado: (2022)

CD36-mediated metabolic crosstalk between tumor cells and macrophages affects liver metastasis
por: Yang, Ping, et al.
Publicado: (2022)

Association between reductions in low-density lipoprotein cholesterol with statin therapy and the risk of new-onset diabetes: a meta-analysis
por: Wang, Shaohua, et al.
Publicado: (2017)

The Efficacy of Flupentixol-Melitracen in the Adjuvant Therapy of Ulcerative Colitis in the Chinese Population: A Meta-Analysis
por: Zhou, Xiaoqian, et al.
Publicado: (2019)

Paradoxical Effects of Rapamycin on Experimental House Dust Mite-Induced Asthma
por: Fredriksson, Karin, et al.
Publicado: (2012)

Rapamycin inhibits lipopolysaccharide-induced neuroinflammation in vitro and in vivo
por: Mengke, Na-Shun, et al.
Publicado: (2016)

Genome-Wide Transcriptome Analysis of CD36 Overexpression in HepG2.2.15 Cells to Explore Its Regulatory Role in Metabolism and the Hepatitis B Virus Life Cycle
por: Huang, Jian, et al.
Publicado: (2016)

Paradoxical response of malignant melanoma to methotrexate in vivo and in vitro.
por: Gaukroger, J., et al.
Publicado: (1983)

Experimental malaria: the in vitro and in vivo blood pressure paradox
por: Nwokocha, CR, et al.
Publicado: (2012)

CD36 Senses Dietary Lipids and Regulates Lipids Homeostasis in the Intestine
por: Zhao, Lei, et al.
Publicado: (2021)

Obesity induces preadipocyte CD36 expression promoting inflammation via the disruption of lysosomal calcium homeostasis and lysosome function
por: Luo, Xiaoxiao, et al.
Publicado: (2020)

Identification of mammalian target of rapamycin as a direct target of fenretinide both in vitro and in vivo
por: Xie, Hua, et al.
Publicado: (2012)

Rapamycin promotes osteogenesis under inflammatory conditions
por: Li, Xing, et al.
Publicado: (2017)

mTOR Blockade by Rapamycin in Spondyloarthritis: Impact on Inflammation and New Bone Formation in vitro and in vivo
por: Chen, Sijia, et al.
Publicado: (2020)

Combined Treatment with Doxorubicin and Rapamycin Is Effective against In Vitro and In Vivo Models of Human Glioblastoma
por: Iorio, Anna Lisa, et al.
Publicado: (2019)

Paradoxical activation of chronic lymphocytic leukemia cells by ruxolitinib in vitro and in vivo
por: Spaner, David E., et al.
Publicado: (2023)

Prostacyclin: An Inflammatory Paradox
por: Stitham, Jeremiah, et al.
Publicado: (2011)

Sterol-resistant SCAP Overexpression in Vascular Smooth Muscle Cells Accelerates Atherosclerosis by Increasing Local Vascular Inflammation through Activation of the NLRP3 Inflammasome in Mice
por: Li, Danyang, et al.
Publicado: (2021)

Resolving the Paradox of Hepatic Insulin Resistance
por: Santoleri, Dominic, et al.
Publicado: (2018)

Insulin-Degrading Enzyme: Paradoxes and Possibilities
por: Leissring, Malcolm A.
Publicado: (2021)

Effects of miR-33a-5P on ABCA1/G1-Mediated Cholesterol Efflux under Inflammatory Stress in THP-1 Macrophages
por: Mao, Min, et al.
Publicado: (2014)

Ameliorated effects of a lipopeptide surfactin on insulin resistance in vitro and in vivo
por: Chen, Xiaoyu, et al.
Publicado: (2022)

The Role of Mammalian Target of Rapamycin (mTOR) in Insulin Signaling
por: Yoon, Mee-Sup
Publicado: (2017)

The role of cytochrome P450 enzymes in carcinogen activation and detoxication: an in vivo–in vitro paradox
por: Reed, Lindsay, et al.
Publicado: (2018)

An in vivo phosphoregulation paradox for focal adhesions
por: Tanner, Kandice
Publicado: (2023)

Corilagin Ameliorates Atherosclerosis in Peripheral Artery Disease via the Toll-Like Receptor-4 Signaling Pathway in vitro and in vivo
por: Li, Yiqing, et al.
Publicado: (2020)

Rapamycin induces glucose intolerance in mice by reducing islet mass, insulin content, and insulin sensitivity
por: Yang, Shi-Bing, et al.
Publicado: (2011)

Inhibition of insulin-like growth factor receptor/AKT/mammalian target of rapamycin axis targets colorectal cancer stem cells by attenuating mevalonate-isoprenoid pathway in vitro and in vivo
por: Sharon, Chetna, et al.
Publicado: (2015)

Once again on rapamycin-induced insulin resistance and longevity: despite of or owing to
por: Blagosklonny, Mikhail V.
Publicado: (2012)

The fatty acid receptor CD36 promotes HCC progression through activating Src/PI3K/AKT axis-dependent aerobic glycolysis
por: Luo, Xiaoqing, et al.
Publicado: (2021)

Rapamycin reverses insulin resistance (IR) in high-glucose medium without causing IR in normoglycemic medium
por: Leontieva, O V, et al.
Publicado: (2014)

Rapamycin Protects Against Peritendinous Fibrosis Through Activation of Autophagy
por: Zheng, Wei, et al.
Publicado: (2018)

Targeting gallbladder cancer: oncolytic virotherapy with myxoma virus is enhanced by rapamycin in vitro and further improved by hyaluronan in vivo
por: Weng, Mingzhe, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_sdomsu0jeuro0kif3k3q6buaqi