BAP1 promotes breast cancer cell proliferation and metastasis by deubiquitinating KLF5

The transcription factor KLF5 is highly expressed in basal-like breast cancer and promotes breast cancer cell proliferation, survival, migration and tumour growth. Here we show that, in breast cancer cells, KLF5 is stabilized by the deubiquitinase (DUB) BAP1. With a genome-wide siRNA library screen...

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Detalles Bibliográficos
Autores principales: Qin, Junying, Zhou, Zhongmei, Chen, Wenlin, Wang, Chunyan, Zhang, Hailin, Ge, Guangzhe, Shao, Ming, You, Dingyun, Fan, Zhixiang, Xia, Houjun, Liu, Rong, Chen, Ceshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4598844/
https://www.ncbi.nlm.nih.gov/pubmed/26419610
http://dx.doi.org/10.1038/ncomms9471

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4598844/
https://www.ncbi.nlm.nih.gov/pubmed/26419610
http://dx.doi.org/10.1038/ncomms9471

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