Conformational switch of polyglutamine-expanded huntingtin into benign aggregates leads to neuroprotective effect

The abundant accumulation of inclusion bodies containing polyglutamine-expanded mutant huntingtin (mHTT) aggregates is considered as the key pathological event in Huntington’s disease (HD). Here, we demonstrate that FKBP12, an isomerase that exhibits reduced expression in HD, decreases the amyloidog...

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Detalles Bibliográficos
Autores principales: Sun, Chia-Sui, Lee, Chi-Chang, Li, Yi-Ni, Yao-Chen Yang, Sunny, Lin, Chih-Hsiang, Chang, Yi-Che, Liu, Po-Fan, He, Ruei-Yu, Wang, Chih-Hsien, Chen, Wenlung, Chern, Yijuang, Jen-Tse Huang, Joseph
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4598856/
https://www.ncbi.nlm.nih.gov/pubmed/26450664
http://dx.doi.org/10.1038/srep14992

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4598856/
https://www.ncbi.nlm.nih.gov/pubmed/26450664
http://dx.doi.org/10.1038/srep14992

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