Proteasome Activation is Mediated via a Functional Switch of the Rpt6 C-terminal Tail Following Chaperone-dependent Assembly

In the proteasome, the proteolytic 20S core particle (CP) associates with the 19S regulatory particle (RP) to degrade polyubiquitinated proteins. Six ATPases (Rpt1-Rpt6) of the RP form a hexameric Rpt ring and interact with the heptameric α ring (α1–α7) of the CP via the Rpt C-terminal tails individ...

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Detalles Bibliográficos
Autores principales: Sokolova, Vladyslava, Li, Frances, Polovin, George, Park, Soyeon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4598862/
https://www.ncbi.nlm.nih.gov/pubmed/26449534
http://dx.doi.org/10.1038/srep14909

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4598862/
https://www.ncbi.nlm.nih.gov/pubmed/26449534
http://dx.doi.org/10.1038/srep14909

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