A PI3K p110β–Rac signalling loop mediates Pten-loss-induced perturbation of haematopoiesis and leukaemogenesis

The tumour suppressor PTEN, which antagonizes PI3K signalling, is frequently inactivated in haematologic malignancies. In mice, deletion of PTEN in haematopoietic stem cells (HSCs) causes perturbed haematopoiesis, myeloproliferative neoplasia (MPN) and leukaemia. Although the roles of the PI3K isofo...

Descripción completa

Detalles Bibliográficos
Autores principales: Yuzugullu, Haluk, Baitsch, Lukas, Von, Thanh, Steiner, Allison, Tong, Haoxuan, Ni, Jing, Clayton, Linda K., Bronson, Roderick, Roberts, Thomas M., Gritsman, Kira, Zhao, Jean J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4598950/
https://www.ncbi.nlm.nih.gov/pubmed/26442967
http://dx.doi.org/10.1038/ncomms9501

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4598950/
https://www.ncbi.nlm.nih.gov/pubmed/26442967
http://dx.doi.org/10.1038/ncomms9501

Ejemplares similares