Anti-DR5 mAb inhibits proliferation of human fibroblast-like synovial cells and reduces their cytokine secretion in vitro

BACKGROUND: We have previously reported that anti-death receptor 5 (DR5) monoclonal antibody (mAb) is therapeutically effective in the treatment of rheumatoid arthritis (RA) in a collagen-induced arthritis rat model. However, the molecular mechanism and the effect of anti-DR5 mAb on proapoptotic gen...

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Detalles Bibliográficos
Autores principales: Zhang, Minping, Shi, Chunyan, Xia, Chun, Yang, Jin, Niu, Xingyang, Zhuang, Guohong, Yin, Ping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2015
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4599060/
https://www.ncbi.nlm.nih.gov/pubmed/26491348
http://dx.doi.org/10.2147/OTT.S87448

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4599060/
https://www.ncbi.nlm.nih.gov/pubmed/26491348
http://dx.doi.org/10.2147/OTT.S87448

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