Cargando…

Circulating primers enhance platelet function and induce resistance to antiplatelet therapy

BACKGROUND: Aspirin and P2Y(12) antagonists are antiplatelet compounds that are used clinically in patients with thrombosis. However, some patients are ‘resistant’ to antiplatelet therapy, which increases their risk of developing acute coronary syndromes. These patients often present with an underly...

Descripción completa

Detalles Bibliográficos
Autores principales:	Blair, T A, Moore, S F, Hers, I
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley & Sons, Ltd 2015
Materias:	Platelets
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4599128/ https://www.ncbi.nlm.nih.gov/pubmed/26039631 http://dx.doi.org/10.1111/jth.13022

Ejemplares similares

Protein kinase C and P2Y(12) take center stage in thrombin-mediated activation of mammalian target of rapamycin complex 1 in human platelets
por: Moore, S F, et al.
Publicado: (2014)

Cytohesin-2 phosphorylation by protein kinase C relieves the constitutive suppression of platelet dense granule secretion by ADP-ribosylation factor 6
por: van den Bosch, M T J, et al.
Publicado: (2014)

Multimerin 1 supports platelet function in vivo and binds to specific GPAGPOGPX motifs in fibrillar collagens that enhance platelet adhesion
por: Leatherdale, Alexander, et al.
Publicado: (2020)

The platelet-surface thiol isomerase enzyme ERp57 modulates platelet function
por: Holbrook, L-M, et al.
Publicado: (2012)

A gain‐of‐function filamin A mutation in mouse platelets induces thrombus instability
por: Adam, Frédéric, et al.
Publicado: (2022)

Anchoring IgG-degrading enzymes to the surface of platelets selectively neutralizes antiplatelet antibodies
por: Lynch, Donald R., et al.
Publicado: (2022)

Antiprothrombin antibodies induce platelet activation: A possible explanation for anti‐FXa therapy failure in patients with antiphospholipid syndrome?
por: Chayoua, Walid, et al.
Publicado: (2021)

Platelet endothelial cell adhesion molecule-1 regulates collagen-stimulated platelet function by modulating the association of phosphatidylinositol 3-kinase with Grb-2-associated binding protein-1 and linker for activation of T cells
por: Moraes, L A, et al.
Publicado: (2010)

Diagnostic utility of the ISTH bleeding assessment tool in patients with suspected platelet function disorders
por: Adler, Marcel, et al.
Publicado: (2019)

Mean platelet size related to glycoprotein-specific autoantibodies and platelet-associated IgG
por: JAVELA, K, et al.
Publicado: (2007)

Measurement of procoagulant platelets provides mechanistic insight and diagnostic potential in heparin‐induced thrombocytopenia
por: Lee, Christine S. M., et al.
Publicado: (2022)

Activation mechanism dependent surface exposure of cellular factor XIII on activated platelets and platelet microparticles
por: Somodi, Laura, et al.
Publicado: (2022)

Enhanced activity of an ADAMTS‐13 variant (R568K/F592Y/R660K/Y661F/Y665F) against platelet agglutination in vitro and in a murine model of acute ischemic stroke
por: South, K., et al.
Publicado: (2018)

SMIFH2 inhibition of platelets demonstrates a critical role for formin proteins in platelet cytoskeletal dynamics
por: Green, Hannah L. H., et al.
Publicado: (2020)

Platelet collagen receptor Glycoprotein VI‐dimer recognizes fibrinogen and fibrin through their D‐domains, contributing to platelet adhesion and activation during thrombus formation
por: Induruwa, I., et al.
Publicado: (2018)

Dimeric FcγR ectodomains detect pathogenic anti‐platelet factor 4–heparin antibodies in heparin‐induced thromobocytopenia
por: Wines, B. D., et al.
Publicado: (2018)

Manipulating megakaryocytes to manufacture platelets ex vivo
por: Karagiannis, P, et al.
Publicado: (2015)

Hypothermia‐induced activation of the splenic platelet pool as a risk factor for thrombotic disease in a mouse model
por: Horioka, Kie, et al.
Publicado: (2019)

Use of next‐generation sequencing and candidate gene analysis to identify underlying defects in patients with inherited platelet function disorders
por: Leo, V. C., et al.
Publicado: (2015)

Effect of heparanase inhibitor on tissue factor overexpression in platelets and endothelial cells induced by anti‐β2‐GPI antibodies
por: Capozzi, Antonella, et al.
Publicado: (2021)

Non-genomic effects of PPARγ ligands: inhibition of GPVI-stimulated platelet activation
por: Moraes, L A, et al.
Publicado: (2010)

The formyl peptide fMLF primes platelet activation and augments thrombus formation
por: Salamah, Maryam F., et al.
Publicado: (2019)

Super‐resolution microscopy as a potential approach to diagnosis of platelet granule disorders
por: Westmoreland, D., et al.
Publicado: (2016)

Amplification of human platelet activation by surface pannexin-1 channels
por: Taylor, K A, et al.
Publicado: (2014)

Akt and mitogen‐activated protein kinase enhance C‐type lectin‐like receptor 2‐mediated platelet activation by inhibition of glycogen synthase kinase 3α/β
por: Moroi, A. J., et al.
Publicado: (2015)

Modified platelet deposition on matrix metalloproteinase 13 digested collagen I
por: Howes, J.‐M., et al.
Publicado: (2015)

Anti‐platelet antibodies in childhood immune thrombocytopenia: Prevalence and prognostic implications
por: Schmidt, David E., et al.
Publicado: (2020)

CLEC‐2‐dependent activation of mouse platelets is weakly inhibited by cAMP but not by cGMP
por: Borgognone, A., et al.
Publicado: (2014)

Flow cytometric mepacrine fluorescence can be used for the exclusion of platelet dense granule deficiency
por: van Asten, Ivar, et al.
Publicado: (2019)

Altered Fc glycosylation of anti‐HLA alloantibodies in hemato‐oncological patients receiving platelet transfusions
por: van Osch, Thijs L. J., et al.
Publicado: (2022)

Differential roles for the adapters Gads and LAT in platelet activation by GPVI and CLEC-2
por: HUGHES, C E, et al.
Publicado: (2008)

Phagocytosis by endothelial cells inhibits procoagulant activity of platelets of essential thrombocythemia in vitro
por: Ji, Shuting, et al.
Publicado: (2019)

Removal of platelets from blood plasma to improve the quality of extracellular vesicle research
por: Bettin, Britta, et al.
Publicado: (2022)

PPARγ agonists negatively regulate αIIbβ3 integrin outside‐in signaling and platelet function through up‐regulation of protein kinase A activity
por: Unsworth, A. J., et al.
Publicado: (2017)

Platelet count and indices as postpartum hemorrhage risk factors: a retrospective cohort study
por: van Dijk, Wobke E. M., et al.
Publicado: (2021)

Maintaining flippase activity in procoagulant platelets is a novel approach to reducing thrombin generation
por: Millington‐Burgess, Sarah L., et al.
Publicado: (2022)

The chaperone protein HSP47: a platelet collagen binding protein that contributes to thrombosis and hemostasis
por: Sasikumar, P., et al.
Publicado: (2018)

Novel assay demonstrates that coronary artery disease patients have heightened procoagulant platelet response
por: Pasalic, L., et al.
Publicado: (2018)

Cleavage by MMP‐13 renders VWF unable to bind to collagen but increases its platelet reactivity
por: Howes, Joanna‐Marie, et al.
Publicado: (2020)

Ca(v)3.2 T‐type calcium channel regulates mouse platelet activation and arterial thrombosis
por: Tamang, Hem Kumar, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_76frfnnmi03loolkola012join