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Structurally diverse c-Myc inhibitors share a common mechanism of action involving ATP depletion

The c-Myc (Myc) oncoprotein is deregulated in a large proportion of diverse human cancers. Considerable effort has therefore been directed at identifying pharmacologic inhibitors as potential anti-neoplastic agents. Three such groups of small molecule inhibitors have been described. The first is com...

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Detalles Bibliográficos
Autores principales: Wang, Huabo, Sharma, Lokendra, Lu, Jie, Finch, Paul, Fletcher, Steven, Prochownik, Edward V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4599242/
https://www.ncbi.nlm.nih.gov/pubmed/26036281