Tanshinone I inhibits tumor angiogenesis by reducing STAT3 phosphorylation at TYR705 and hypoxia-induced HIF-1α accumulation in both endothelial and tumor cells

Tanshinone I (Tanshinone-1), a major active principle of Salvia miltiorrhiza (Danshen), has been shown to overcome tumor drug resistance and metastasis. Here we report that tanshinone-1 inhibits angiogenesis. Tanshinone-1 inhibited proliferation, migration and tube formation of vascular endothelial...

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Detalles Bibliográficos
Autores principales: Wang, Yan, Li, Jia-Xin, Wang, Ying-Qing, Miao, Ze-Hong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4599254/
https://www.ncbi.nlm.nih.gov/pubmed/26202747

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4599254/
https://www.ncbi.nlm.nih.gov/pubmed/26202747

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