Notch signaling sustains the expression of Mcl-1 and the activity of eIF4E to promote cell survival in CLL

In chronic lymphocytic leukemia (CLL), Notch1 and Notch2 signaling is constitutively activated and contributes to apoptosis resistance. We show that genetic inhibition of either Notch1 or Notch2, through small-interfering RNA, increases apoptosis of CLL cells and is associated with decreased levels...

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Detalles Bibliográficos
Autores principales: De Falco, Filomena, Sabatini, Rita, Del Papa, Beatrice, Falzetti, Franca, Di Ianni, Mauro, Sportoletti, Paolo, Baldoni, Stefano, Screpanti, Isabella, Marconi, Pierfrancesco, Rosati, Emanuela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4599289/
https://www.ncbi.nlm.nih.gov/pubmed/26041884

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4599289/
https://www.ncbi.nlm.nih.gov/pubmed/26041884

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