Many obesity-associated SNPs strongly associate with DNA methylation changes at proximal promoters and enhancers

BACKGROUND: The mechanisms by which genetic variants, such as single nucleotide polymorphisms (SNPs), identified in genome-wide association studies act to influence body mass remain unknown for most of these SNPs, which continue to puzzle the scientific community. Recent evidence points to the epige...

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Detalles Bibliográficos
Autores principales: Voisin, Sarah, Almén, Markus Sällman, Zheleznyakova, Galina Y., Lundberg, Lina, Zarei, Sanaz, Castillo, Sandra, Eriksson, Fia Ence, Nilsson, Emil K., Blüher, Matthias, Böttcher, Yvonne, Kovacs, Peter, Klovins, Janis, Rask-Andersen, Mathias, Schiöth, Helgi B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4599317/
https://www.ncbi.nlm.nih.gov/pubmed/26449484
http://dx.doi.org/10.1186/s13073-015-0225-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4599317/
https://www.ncbi.nlm.nih.gov/pubmed/26449484
http://dx.doi.org/10.1186/s13073-015-0225-4

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