Cargando…

Many obesity-associated SNPs strongly associate with DNA methylation changes at proximal promoters and enhancers

BACKGROUND: The mechanisms by which genetic variants, such as single nucleotide polymorphisms (SNPs), identified in genome-wide association studies act to influence body mass remain unknown for most of these SNPs, which continue to puzzle the scientific community. Recent evidence points to the epige...

Descripción completa

Detalles Bibliográficos
Autores principales:	Voisin, Sarah, Almén, Markus Sällman, Zheleznyakova, Galina Y., Lundberg, Lina, Zarei, Sanaz, Castillo, Sandra, Eriksson, Fia Ence, Nilsson, Emil K., Blüher, Matthias, Böttcher, Yvonne, Kovacs, Peter, Klovins, Janis, Rask-Andersen, Mathias, Schiöth, Helgi B.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2015
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4599317/ https://www.ncbi.nlm.nih.gov/pubmed/26449484 http://dx.doi.org/10.1186/s13073-015-0225-4

Ejemplares similares

meQTL and ncRNA functional analyses of 102 GWAS-SNPs associated with depression implicate HACE1 and SHANK2 genes
por: Ciuculete, Diana M., et al.
Publicado: (2020)

The Dispanins: A Novel Gene Family of Ancient Origin That Contains 14 Human Members
por: Sällman Almén, Markus, et al.
Publicado: (2012)

The Origin of GPCRs: Identification of Mammalian like Rhodopsin, Adhesion, Glutamate and Frizzled GPCRs in Fungi
por: Krishnan, Arunkumar, et al.
Publicado: (2012)

Insights into the Origin of Nematode Chemosensory GPCRs: Putative Orthologs of the Srw Family Are Found across Several Phyla of Protostomes
por: Krishnan, Arunkumar, et al.
Publicado: (2014)

BDNF DNA methylation changes as a biomarker of psychiatric disorders: literature review and open access database analysis
por: Zheleznyakova, Galina Y., et al.
Publicado: (2016)

Mapping the human membrane proteome: a majority of the human membrane proteins can be classified according to function and evolutionary origin
por: Almén, Markus Sällman, et al.
Publicado: (2009)

Highly diversified expansions shaped the evolution of membrane bound proteins in metazoans
por: Attwood, Misty M., et al.
Publicado: (2017)

Functional coupling analysis suggests link between the obesity gene FTO and the BDNF-NTRK2 signaling pathway
por: Rask-Andersen, Mathias, et al.
Publicado: (2011)

Functional specialization in nucleotide sugar transporters occurred through differentiation of the gene cluster EamA (DUF6) before the radiation of Viridiplantae
por: Västermark, Åke, et al.
Publicado: (2011)

Roux-En Y Gastric Bypass Surgery Induces Genome-Wide Promoter-Specific Changes in DNA Methylation in Whole Blood of Obese Patients
por: Nilsson, Emil K., et al.
Publicado: (2015)

Association between a rare SNP in the second intron of human Agouti related protein gene and increased BMI
por: Kalnina, Ineta, et al.
Publicado: (2009)

Topology based identification and comprehensive classification of four-transmembrane helix containing proteins (4TMs) in the human genome
por: Attwood, Misty M., et al.
Publicado: (2016)

Dietary fat quality impacts genome-wide DNA methylation patterns in a cross-sectional study of Greek preadolescents
por: Voisin, Sarah, et al.
Publicado: (2015)

Genetic and expression studies of SMN2 gene in Russian patients with spinal muscular atrophy type II and III
por: Zheleznyakova, Galina Yu, et al.
Publicado: (2011)

The GPCR repertoire in the demosponge Amphimedon queenslandica: insights into the GPCR system at the early divergence of animals
por: Krishnan, Arunkumar, et al.
Publicado: (2014)

The Association of Common SNPs and Haplotypes in CETP Gene with HDL Cholesterol Levels in Latvian Population
por: Radovica, Ilze, et al.
Publicado: (2013)

Determination of the obesity-associated gene variants within the entire FTO gene by ultra-deep targeted sequencing in obese and lean children
por: Sällman Almén, M, et al.
Publicado: (2013)

Identification of somatostatin receptor type 5 gene polymorphisms associated with acromegaly
por: Ciganoka, Darja, et al.
Publicado: (2011)

The obesity gene, TMEM18, is of ancient origin, found in majority of neuronal cells in all major brain regions and associated with obesity in severely obese children
por: Almén, Markus Sällman, et al.
Publicado: (2010)

Detailed Analysis of Variants in FTO in Association with Body Composition in a Cohort of 70-Year-Olds Suggests a Weakened Effect among Elderly
por: Jacobsson, Josefin A., et al.
Publicado: (2011)

Methylation Levels of SLC23A2 and NCOR2 Genes Correlate with Spinal Muscular Atrophy Severity
por: Zheleznyakova, Galina Yu., et al.
Publicado: (2015)

Functional characterization of two melanocortin (MC) receptors in lamprey showing orthology to the MC1 and MC4 receptor subtypes
por: Haitina, Tatjana, et al.
Publicado: (2007)

Obesity-Linked Homologues TfAP-2 and Twz Establish Meal Frequency in Drosophila melanogaster
por: Williams, Michael J., et al.
Publicado: (2014)

Personality, lifestyle and job satisfaction: causal association between neuroticism and job satisfaction using Mendelian randomisation in the UK biobank cohort
por: Rukh, Gull, et al.
Publicado: (2020)

Longitudinal genome-wide methylation study of Roux-en-Y gastric bypass patients reveals novel CpG sites associated with essential hypertension
por: Boström, Adrian E., et al.
Publicado: (2016)

A debate on current eating disorder diagnoses in light of neurobiological findings: is it time for a spectrum model?
por: Brooks, Samantha Jane, et al.
Publicado: (2012)

A methylome-wide mQTL analysis reveals associations of methylation sites with GAD1 and HDAC3 SNPs and a general psychiatric risk score
por: Ciuculete, D M, et al.
Publicado: (2017)

The STK33-Linked SNP rs4929949 Is Associated with Obesity and BMI in Two Independent Cohorts of Swedish and Greek Children
por: Rask-Andersen, Mathias, et al.
Publicado: (2013)

CDKAL1-Related Single Nucleotide Polymorphisms Are Associated with Insulin Resistance in a Cross-Sectional Cohort of Greek Children
por: Rask-Andersen, Mathias, et al.
Publicado: (2014)

Assessing effectiveness of many-objective evolutionary algorithms for selection of tag SNPs
por: Moqa, Rashad, et al.
Publicado: (2022)

A Genetic Risk Score Is Associated with Weight Loss Following Roux-en Y Gastric Bypass Surgery
por: Bandstein, Marcus, et al.
Publicado: (2016)

Kiwi genome provides insights into evolution of a nocturnal lifestyle
por: Le Duc, Diana, et al.
Publicado: (2015)

Depression and Vegetarians: Association between Dietary Vitamin B6, B12 and Folate Intake and Global and Subcortical Brain Volumes
por: Berkins, Samuel, et al.
Publicado: (2021)

The MAP2K5-linked SNP rs2241423 is associated with BMI and obesity in two cohorts of Swedish and Greek children
por: Rask-Andersen, Mathias, et al.
Publicado: (2012)

Can Exposure to Environmental Pollutants Be Associated with Less Effective Chemotherapy in Cancer Patients?
por: Lagunas-Rangel, Francisco Alejandro, et al.
Publicado: (2022)

Significantly altered peripheral blood cell DNA methylation profile as a result of immediate effect of metformin use in healthy individuals
por: Elbere, Ilze, et al.
Publicado: (2018)

Longitudinal DNA methylation changes at MET may alter HGF/c-MET signalling in adolescents at risk for depression
por: Ciuculete, Diana M., et al.
Publicado: (2019)

Job satisfaction has differential associations with delay discounting and risk-taking
por: de Ruijter, Markus J. T., et al.
Publicado: (2023)

Shrunken Pore Syndrome Is Associated With Increased Levels of Atherosclerosis-Promoting Proteins
por: Almén, Markus Sällman, et al.
Publicado: (2018)

The Drosophila ETV5 Homologue Ets96B: Molecular Link between Obesity and Bipolar Disorder
por: Williams, Michael J., et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_2feav1gsrbvapntjs3v4j3ufg1