Safety, tolerability, pharmacokinetics, and efficacy of AMG 403, a human anti-nerve growth factor monoclonal antibody, in two phase I studies with healthy volunteers and knee osteoarthritis subjects

INTRODUCTION: Nerve growth factor plays a key role in the pathology of osteoarthritis (OA) related chronic pain. The aim of these studies was to evaluate the safety, tolerability, pharmacokinetics, and clinical response of AMG 403, a human anti-nerve growth factor monoclonal antibody, in healthy vol...

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Detalles Bibliográficos
Autores principales: Gow, Jason M., Tsuji, Wayne H., Williams, Gary J., Mytych, Daniel, Sciberras, David, Searle, Shawn L., Mant, Tim, Gibbs, John P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4599327/
https://www.ncbi.nlm.nih.gov/pubmed/26449617
http://dx.doi.org/10.1186/s13075-015-0797-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4599327/
https://www.ncbi.nlm.nih.gov/pubmed/26449617
http://dx.doi.org/10.1186/s13075-015-0797-9

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