Enhanced production of a single domain antibody with an engineered stabilizing extra disulfide bond

BACKGROUND: Single domain antibodies derived from the variable region of the unique heavy chain antibodies found in camelids yield high affinity and regenerable recognition elements. Adding an additional disulfide bond that bridges framework regions is a proven method to increase their melting tempe...

Descripción completa

Detalles Bibliográficos
Autores principales: Liu, Jinny L., Goldman, Ellen R., Zabetakis, Dan, Walper, Scott A., Turner, Kendrick B., Shriver-Lake, Lisa C., Anderson, George P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4599338/
https://www.ncbi.nlm.nih.gov/pubmed/26449768
http://dx.doi.org/10.1186/s12934-015-0340-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4599338/
https://www.ncbi.nlm.nih.gov/pubmed/26449768
http://dx.doi.org/10.1186/s12934-015-0340-3

Ejemplares similares